Air pollution may be damaging every organ and virtually every cell in the human body, according to a comprehensive new global review.
The research shows head-to-toe harm, from heart and lung disease to diabetes and dementia, and from liver problems and bladder cancer to brittle bones and damaged skin. Fertility, foetuses and children are also affected by toxic air, the review found.
The systemic damage is the result of pollutants causing inflammation that then floods through the body and ultrafine particles being carried around the body by the bloodstream.
Air pollution is a “public health emergency”, according to the World Health Organization, with more than 90% of the global population enduring toxic outdoor air. New analysis indicates 8.8m early deaths each year – double earlier estimates – making air pollution a bigger killer than tobacco smoking.
But the impact of different pollutants on many ailments remains to be established, suggesting well-known heart and lung damage is only “the tip of the iceberg”.
“Air pollution can harm acutely, as well as chronically, potentially affecting every organ in the body,” conclude the scientists from the Forum of International Respiratory Societies in the two review papers, published in the journal Chest. “Ultrafine particles pass through the [lungs], are readily picked up by cells, and carried via the bloodstream to expose virtually all cells in the body.”
Prof Dean Schraufnagel, at the University of Illinois at Chicago and who led the reviews, said: “I wouldn’t be surprised if almost every organ was affected. If something is missing [from the review] it is probably because there was no research yet.”
The review represents “very strong science”, said Dr Maria Neira, WHO director of public and environmental health: “It adds to the very heavy evidence we have already. There are more than 70,000 scientific papers to demonstrate that air pollution is affecting our health.”
She said she expected even more impacts of air pollution to be shown by future research: “Issues like Parkinson’s or autism, for which there is some evidence but maybe not the very strong linkages, that evidence is coming now.”
How air pollution reaches every part of the body ...
The WHO has called air pollution the “silent killer” because its widespread effects are often not ascribed to toxic air.
Lungs and heart
The harmful effects of dirty air shown in the review begin when the pollution is inhaled.
This results in breathing problems, from asthma to emphysema to lung cancer. There is now overwhelming evidence that air pollution results in serious harm not only to the lungs, but also to the heart. Here it increases the risk of heart attacks as arteries narrow and muscles weaken.
One reason for the wide-ranging damage from air pollution is that very small particles can penetrate the lungs and be carried around the body. “They land in the organs directly,” Schraufnagel said.
“Animal studies have shown they can even travel right up the olfactory nerve into the brain.” An emerging area of research also suggests air pollution can affect how genes function, he added.
Brain and mind
Strokes, dementia and reduced intelligence are all conditions affecting the brain that have been linked to air pollution.
There is also evidence that poor sleep can be a consequence of breathing toxic air.
The main reason for the far-reaching damage from air pollution is systemic inflammation, said Schraufnagel.
“Immune cells think a [pollution particle] is a bacteria, go after it and try to kill it by releasing enzymes and acids,” he said.
“Those inflammatory proteins spread into the body, affecting the brain, the kidneys, the pancreas and so forth. In evolutionary terms, the body has evolved to defend itself against infections, not pollution.”
Among the many other organs affected is the liver. Schraufnagel said the latter surprised him, until he thought about the liver’s role in removing toxins from the body: “It makes perfect sense, but I would not have thought about it before starting the study.”
Research highlighted in the review also links air pollution to numerous cancers, including in the bladder and the gut, where an increase in irritable bowel syndrome has also been found.
Even skin and bones are affected, with skin ageing, hives and brittle bones associated with toxic air.
Reproduction, babies and children
Perhaps the most disturbing impact of toxic air is the damage to reproduction and children. Fertility is reduced and miscarriages increased by exposure to air pollution.
The unborn are also affected, with a recent study finding pollutants in the placentas that nourish foetuses.
Air pollution is also strongly linked to low birthweights for babies, which has lifelong consequences.
Children are especially vulnerable, the review found, as their bodies are still developing.